Searsia species with affinity to the N-methyl-d-aspartic acid (NMDA) receptor

Regulation of N-methyl-D-aspartic acid (NMDA) receptors by metabotropic glutamate receptor 7.

Emerging evidence suggests that metabotropic glutamate receptors (mGluRs) are potential novel targets for brain disorders associated with the dysfunction of prefrontal cortex (PFC), a region critical for cognitive and emotional processes. Because N-methyl-D-aspartic acid receptor (NMDAR) dysregulation has been strongly associated with the pathophysiology of mental illnesses, we examined the pos...

N-methyl-D-aspartic acid receptor structure and function.

Paraneoplastic Anti-N-Methyl-D-Aspartic Acid Receptor Encephalitis

MLR Mesencephalic Locomotor Region MN Motor Neuron NMDA N - Methyl - D - aspartic acid

Abbreviations 5HT 5-hydroxytryptamine BG Basal ganglia BSN Brainstem nuclei Cer Cerebellum Chx10 Ceh-10 homeodomain-containing homolog CN Commissural Neuron CPG Central Pattern Generator Dbx1 Developing brain homeobox 1 DSCT Dorsal spinocerebellar tract eCN excitatory commissural neuron eIN excitatory interneuron En1 Engrailed 1 Evx1 Even-skipped homeobox FP Floor Plate GATA GATA binding protei...

N-Hydroxypyrazolyl glycine derivatives as selective N-methyl-D-aspartic acid receptor ligands.

A series of analogues based on N-hydroxypyrazole as a bioisostere for the distal carboxylate group of aspartate have been designed, synthesized, and pharmacologically characterized. Affinity studies on the major glutamate receptor subgroups show that these 4-substituted N-hydroxypyrazol-5-yl glycine (NHP5G) derivatives are selectively recognized by N-methyl- d-aspartic acid (NMDA) receptors and...